033 TIPE1 is induced in psoriasis lesions and promotes keratinocyte proliferation
نویسندگان
چکیده
منابع مشابه
MiR-217 is down-regulated in psoriasis and promotes keratinocyte differentiation via targeting GRHL2.
MiR-217 is a well-known tumor suppressor, and its down-regulation has been shown in a wide range of solid and leukaemic cancers. However, the biological role of miR-217 in psoriasis pathogenesis, especially in keratinocyte hyperproliferation and differentiation, is not clearly understood. In this study, we found the expression of miR-217 was markedly down-regulated in psoriasis keratinocytes of...
متن کاملTRB3 is elevated in psoriasis vulgaris lesions and mediates HaCaT cells proliferation in vitro
Psoriasis is a chronic skin disease characterized by abnormal keratinocyte proliferation and differentiation, inflammation, and angiogenesis. Overexpression of tribbles homolog3 (TRB3), which belongs to the tribbles family of pseudokinases, has been found in several human tumors and metabolic diseases, but its role in psoriasis has not been fully clarified. The aim of this study is to investiga...
متن کاملMicroRNA-194 regulates keratinocyte proliferation and differentiation by targeting Grainyhead-like 2 in psoriasis.
MicroRNAs (miRNAs) are currently emerged as important regulators in psoriasis. Psoriasis is characterized by hyperproliferation and impaired differentiation of keratinocytes in skin lesions. miR-194 is a well-known regulator of cell proliferation and differentiation. However, the role of miR-194 in psoriasis pathogenesis remains unclear. In this study we aimed to investigate the role of miR-194...
متن کاملKeratinocyte growth factor-induced proliferation of rat airway epithelium is restricted to Clara cells in vivo.
Keratinocyte growth factor (KGF) is a potent mitogen of pulmonary bronchial and alveolar epithelial cells. However, it is unclear which type(s) of airway epithelial cells (AEC) proliferate(s) in response to KGF. AEC proliferation was induced in rats by either endobronchial instillation of 5 mg recombinant human (rHu) KGF per kg body weight or by adenoviral transfer of the human KGF gene (Ad5-Hu...
متن کاملFibrin Stimulates Keratinocyte Proliferation
Received February 9, 2005; revision accepted for publication June 21, 2005. Correspondence: Misa Yamamoto, MT (Medical Technologist), CT (Cytologist), Faculty of Health Sciences, Yamaguchi University School of Medicine, MinamiKogushi 1-1-1, Ube, Yamaguchi, 755-8554, Japan. e-mail: [email protected] Fibrin Stimulates the Proliferation of Human Keratinocytes through the Autocrine Mechani...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.03.109